Sensation is dispensable for the maturation of the vestibulo-ocular reflex

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-01-02 DOI:10.1126/science.adr9982

Paige Leary, Celine Bellegarda, Cheryl Quainoo, Dena Goldblatt, Başak Rosti, David Schoppik

引用次数: 0

Abstract

Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. Development of the neuromuscular junction, and not sensory experience, therefore determines the rate of maturation of an ancient behavior.

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感觉对于前庭眼反射的成熟是不可缺少的

脊椎动物通过一种神经回路来稳定凝视，这种神经回路将感觉的不稳定转化为眼睛的代偿性反旋转。感官反馈在一生中调节着前庭-眼反射。研究了有感觉和无感觉斑马鱼幼体前庭-眼反射回路各组成部分的功能发育。盲鱼能正常地稳定视线，对身体倾斜的神经反应在行为之前就成熟了。相比之下，运动神经元和眼肌之间的突触成熟的时间过程与行为成熟相似。没有前庭感觉经验但有成熟的神经肌肉连接的幼虫有强烈的前庭-眼反射。因此，决定古代行为成熟速度的是神经肌肉连接处的发育，而不是感觉经验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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