Do not overlook the role of fructose in obesity

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-01-03 DOI:10.1038/s42255-024-01198-2

Takahiko Nakagawa, Richard J. Johnson

引用次数: 0

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不要忽视果糖在肥胖中的作用

最近的一篇关于肥胖发病机制的Perspective1研究了能量平衡模型和碳水化合物-胰岛素模型，讨论了体重增加的危险因素，并有一个目标“讨论体重增加的所谓因果因素的重要性”。然而，它忽视了果糖代谢在肥胖发展中的重要作用。现在有大量的数据表明，饮食中的果糖或葡萄糖内源性产生的果糖可能与肥胖有关。事实上，有证据表明，果糖代谢可能通过影响大脑和肝脏的调节机制，刺激食物摄入，减少静息能量代谢，从而在能量平衡模型中发挥作用3,4,5,6，它还可能诱导高胰岛素血症和胰岛素抵抗，这可能解释了碳水化合物-胰岛素模型的许多效应7,8。这些发现表明果糖代谢可能提供了连接碳水化合物-胰岛素和能量平衡模型的统一途径9。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.