[Research Advance of Single Cell Sequencing Technology in Acute Myeloid Leukemia--Review].

Abstract

Acute myeloid leukemia (AML) is the most common and highly heterogeneous acute leukemia in adults. Despite the continuous optimization of prognostic risk stratification and treatment regimens, the overall long-term survival rate of AML patients remains low. The emergence of single cell sequencing (SCS) technology has overcome the defects of traditional sequencing to a certain extent, and realized the transformation of the research of malignant tumors from cell population level to single cell level. Consequently, it has been widely applied in many biological fields. This review mainly focuses on the application of SCS technology in the analysis of tumor heterogeneity, disease evolution, changes in tumor microenvironment, elucidation of drug resistance mechanisms and search for potential therapeutic targets in AML.