Curcumin-based nanofibers: A promising approach for cancer therapy

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-02-01 DOI:10.1016/j.prp.2024.155791

Niloufar Rahiman , Prashant Kesharwani , Sercan Karav , Amirhossein Sahebkar

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引用次数: 0

Abstract

Nanofibers are among the promising platforms for efficient delivery of drugs (both hydrophilic and hydrophobic) through harnessing polymers with different natures as their base. Hydrophobic low-solubility agents such as curcumin could be incorporated in various types of electrospun nanofibers for different aims in drug delivery, such as enhancing its solubility, making this agent sustained release with improved pharmacological efficacy. Through using this nanoplatform, curcumin may become more bioavailable and more efficcious in the field of cancer therapy as well as tissue engineering and wound healing for local delivery of this anti-inflammatory and antioxidant agent. In this review, the characteristics of curcumin-loaded nanofibers, their targeting potential or stimuli-responsiveness accompanied with therapeutic anti-cancerous applications of them (mostly in local application) are securitized. These nanofibers follow the aim of enhancing curcumin's therapeutic effectiveness and release profile. We laso elaborate on the mechanisms of action through which curcumin exerts its effect on various cancerous cells after its incorporation in various types of nanofibers which have been prepared by exploiting different polymers.

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基于姜黄素的纳米纤维：一种有前途的癌症治疗方法。

通过利用不同性质的聚合物作为其基础，纳米纤维是有效输送药物（亲水性和疏水性）的有前途的平台之一。将姜黄素等疏水低溶解度药物掺入到各种类型的静电纺纳米纤维中，以达到提高其溶解度等不同的给药目的，使其缓释，提高药物的药理功效。通过使用这种纳米平台，姜黄素在癌症治疗、组织工程和伤口愈合等领域的生物利用度和有效性可能会更高，因为姜黄素是一种抗炎和抗氧化剂。本文综述了载姜黄素纳米纤维的特性、靶向潜力和刺激反应性，以及它们在抗癌治疗中的应用（主要是局部应用）。这些纳米纤维的目的是提高姜黄素的治疗效果和释放谱。本文还详细阐述了姜黄素掺入不同聚合物制备的纳米纤维后对多种癌细胞的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.