Gas gangrene due to Clostridium haemolyticum in a cat with aortic thromboembolism treated using clopidogrel and rivaroxaban

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
C Simpson, M Baranger-Ete, J Leung, K Worthing, R Malik
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引用次数: 0

Abstract

A 12-year-old Bengal cat with unclassified cardiomyopathy presented for signs consistent with aortic thromboembolism (ATE). It was treated with clopidogrel and rivaroxaban as antithrombotic therapy, combined with narcotic analgesia and frusemide. After initially making a clinical improvement, the cat's condition suddenly deteriorated, with a presumptive diagnosis of clostridial myonecrosis. We posit that ischaemia due to ATE allowed dormant clostridial spores in the left hindlimb to germinate and multiply vegetatively, resulting in the elaboration of potent Gram-positive exotoxins, resulting in the clinical syndrome of gas gangrene, with emphysematous change in the affected limb. Samples collected following euthanasia confirmed the presumptive diagnosis, and Clostridium haemolyticum was isolated after prolonged anaerobic broth culture. The authors propose that benzyl penicillin be given intravenously to cats with ATE as bacterial prophylaxis to prevent this unusual but devastating sequela developing.

使用氯吡格雷和利伐沙班治疗主动脉血栓栓塞猫的溶血性梭菌所致气性坏疽。
一只12岁的孟加拉猫,患有未分类的心肌病,表现出与主动脉血栓栓塞(ATE)一致的体征。给予氯吡格雷和利伐沙班抗栓治疗,并联合麻醉镇痛和氟塞米。在最初的临床改善后,猫的病情突然恶化,推定诊断为梭状肌坏死。我们假设ATE引起的缺血允许左后肢休眠的梭状芽孢萌发和营养繁殖,导致强效力的革兰氏阳性外毒素的形成,导致气性坏疽的临床综合征,并在受影响的肢体发生肺气肿变化。安乐死后收集的样本证实了假定的诊断,并在长时间的厌氧肉汤培养后分离出溶血梭菌。作者建议给患有ATE的猫静脉注射青霉素作为细菌预防,以防止这种不寻常但破坏性的后遗症的发展。
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来源期刊
Australian Veterinary Journal
Australian Veterinary Journal 农林科学-兽医学
CiteScore
2.40
自引率
0.00%
发文量
85
审稿时长
18-36 weeks
期刊介绍: Over the past 80 years, the Australian Veterinary Journal (AVJ) has been providing the veterinary profession with leading edge clinical and scientific research, case reports, reviews. news and timely coverage of industry issues. AJV is Australia''s premier veterinary science text and is distributed monthly to over 5,500 Australian Veterinary Association members and subscribers.
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