Association of hemoglobin levels with metabolic traits in women with PCOS

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Acta Obstetricia et Gynecologica Scandinavica Pub Date : 2024-12-30 DOI:10.1111/aogs.15047

Nikke Virtanen, Emilia Pesonen, Ulla Saarela, Elisa Hurskainen, Riikka K. Arffman, Peppi Koivunen, Terhi Piltonen

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Abstract

Introduction

Within normal variation, higher hemoglobin (Hb) levels are associated with poorer metabolic profile in population cohorts, underlying the link between oxygen delivery and cell metabolism. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women and is commonly accompanied by metabolic derangements. In this study we sought to investigate Hb levels, and their metabolic associations, in women with PCOS.

Material and Methods

We used data from Northern Finland Birth Cohort 1966 to evaluate Hb levels in women with or without PCOS at the ages of 31 and 46 years. Linear regression models were used to investigate associations between Hb levels and essential metabolic parameters in both groups.

Results

Women with PCOS had higher Hb levels than controls at the age of 31 years but not at the age of 46 years. Hb levels were associated positively with most of the metabolic parameters tested (body mass index, waist circumference, fasting insulin, homeostatic model assessment–insulin resistance (HOMA-IR), blood pressure, inflammatory markers, and blood lipids), with stronger associations in women with PCOS than in non-PCOS controls. There were fewer associations at the age of 46 than at 31 years, and body mass index seemed to explain many, though not all, differences between the PCOS and non-PCOS groups.

Conclusions

Women with PCOS have higher Hb levels at the age of 31 years. In both women with and without PCOS, Hb levels associate with poorer metabolic profile.

Abstract Image

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多囊卵巢综合症女性血红蛋白水平与代谢特征的关系。

在正常变化范围内，较高的血红蛋白（Hb）水平与人群中较差的代谢特征相关，这是氧气输送和细胞代谢之间联系的基础。多囊卵巢综合征（PCOS）是女性最常见的内分泌疾病，通常伴有代谢紊乱。在这项研究中，我们试图调查多囊卵巢综合征女性的Hb水平及其代谢相关性。材料和方法：我们使用1966年芬兰北部出生队列的数据来评估31岁和46岁有或没有多囊卵巢综合征的妇女的Hb水平。线性回归模型用于研究两组患者血红蛋白水平与基本代谢参数之间的关系。结果：多囊卵巢综合征女性在31岁时Hb水平高于对照组，而在46岁时Hb水平高于对照组。Hb水平与测试的大多数代谢参数（体重指数、腰围、空腹胰岛素、稳态模型评估-胰岛素抵抗（HOMA-IR）、血压、炎症标志物和血脂）呈正相关，与PCOS女性的相关性强于非PCOS对照组。46岁时的关联比31岁时要少，体重指数似乎可以解释多囊卵巢综合征和非多囊卵巢综合征患者之间的许多差异，尽管不是全部。结论：多囊卵巢综合征女性在31岁时有较高的Hb水平。在有和没有多囊卵巢综合征的妇女中，Hb水平与较差的代谢特征相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Obstetricia et Gynecologica Scandinavica 医学-妇产科学

CiteScore

8.00

自引率

4.70%

发文量

180

审稿时长

3-6 weeks

期刊介绍： Published monthly, Acta Obstetricia et Gynecologica Scandinavica is an international journal dedicated to providing the very latest information on the results of both clinical, basic and translational research work related to all aspects of women’s health from around the globe. The journal regularly publishes commentaries, reviews, and original articles on a wide variety of topics including: gynecology, pregnancy, birth, female urology, gynecologic oncology, fertility and reproductive biology.