Evaluation of susceptibility to pyrazinamide and streptomycin, isoniazid, rifampin and ethambutol of Mycobacterium caprae strains isolated from European bison (Bison bonasus caucasicus) in the Bieszczady Mountains (Southern Poland).

A Didkowska, M Krajewska-Wędzina, A Nowakiewicz, B Orłowska, M Bochniarz, M Kozińska, W Wójcik, M Weiner, K Anusz
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Abstract

The material for drug resistance testing was 28 strains of Mycobacterium caprae isolated from tissue collected post mortem from a free-living Bieszczady Mountain European bison (Bison bonasus caucasicus) herd. All drug susceptibility tests were carried out on an automated Bactec mycobacterial growth indicator tube (MGIT) 960 system, using Bactec MGIT 960 streptomycin, isoniazid, rifampin and ethambutol (S.I.R.E.) and Bactec MGIT 960 PZA kits. The analyzed M. caprae strains demonstrated susceptibility to PZA and the complement of four basic anti-mycobacterial drugs: S.I.R.E. Considering that we are dealing with multidrug-resistant and extremely drug-resistant tuberculosis more and more often, and that no new drugs have been discovered or developed for over 60 years, the study of drug resistance in free-living animal strains of MTBC is of great importance for the deepening and broadening of our knowledge of TB.

波兰南部Bieszczady山区欧洲野牛(bison bonasus caucasicus)分离的卡普拉分枝杆菌菌株对吡嗪酰胺、链霉素、异烟肼、利福平和乙胺丁醇的敏感性评价
耐药性试验的材料是28株从自由生活的比什恰迪山欧洲野牛(bison bonasus caucasicus)群死后组织中分离的卡普勒分枝杆菌。所有药敏试验均在Bactec分枝杆菌生长指示管(MGIT) 960自动系统上进行,使用Bactec MGIT 960链霉素、异烟肼、利福平和乙胺丁醇(S.I.R.E.)和Bactec MGIT 960 PZA试剂盒。所分析的M. caprae菌株对PZA和四种基本抗分枝杆菌药物sisir . e的易感,考虑到我们越来越多地处理多重耐药和极耐药结核病,并且60多年来没有发现或开发新药,研究自由生活动物MTBC菌株的耐药性对于加深和拓宽我们对结核病的认识具有重要意义。
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