Harnessing microbes for heavy metal remediation: mechanisms and prospects

Abstract

Contamination by heavy metals (HMs) poses a significant threat to the ecosystem and its associated micro and macroorganisms, leading to ill effects on humans which necessitate the requirement of effective remediation strategies. Microbial remediation leverages the natural metabolic abilities of microbes to overcome heavy metal pollution effectively. Some of the mechanisms that aids in the removal of heavy metals includes bioaccumulation, biosorption, and biomineralization. Metals such as Cd, Pb, As, Hg, and Cr are passively adsorbed by energy independent process onto the surface by exopolysaccharide sequestration or utilizing energy to transfer metals into the cell and interact with the biomolecules to be sequestered, or being converted into its various valencies, thereby reducing the toxicity. Application of hyperaccumulators has shown to be effective in the removal of HMs especially while augmented with microbes to the rhizosphere region. Omics studies which include metabolomics and metagenomics provide significant information about the microbial diversities and metabolic processes involved in heavy metal remediation, allowing the development of more reliable and sustainable bioremediation approaches. This review also summarizes the recent advancements in microbial remediation, including genetic engineering and nanotechnology that has revolutionized and offered an unprecedented control and precision in the removal of HMs. These innovations hold a promising stand for enhancing remediation efficiency, scalability, and cost-effectiveness.