Antimonotungstate-Based Heterometallic Framework Formed by the Synergistic Strategy of In Situ-Generated Krebs-Type Building Units and the Substitution Reaction and Its High-Efficiency Biosensing KRAS Gene

IF 4.3 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2024-12-31 DOI:10.1021/acs.inorgchem.4c04589

Peijun Gong, Yanying Wang, Junwei Zhao, Guo-Yu Yang

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引用次数: 0

Abstract

A novel antimonotungstate (AT)-based heterometallic framework {[Er(H₂O)₆]₂[Fe₄(H₂pdc)₄(B-β-SbW₉O₃₃)₂]}·50H₂O (1, H₂pdc = pyridine-2,5-dicarboxylic acid) was obtained through a synergistic strategy of in situ-generated transition-metal-encapsulated polyoxometalate (POM) building units and the substitution reaction. Its structural unit is composed of a tetra-Fe^III-substituted Krebs-type [Fe₄(H₂pdc)₄(B-β-SbW₉O₃₃)₂]^6– subunit and two [Er(H₂O)₆]³⁺ cations. This subunit can be regarded as a product of carboxylic oxygen atoms of H₂pdc ligands replacing active water ligands in the [Fe₄(H₂O)₁₀(B-β-SbW₉O₃₃)₂]^6– species. Apparently, the substitution action of carboxylic oxygen atoms of H₂pdc ligands for active water ligands, together with the coordination function of Er³⁺ ions, plays a connection role in the architecture of the three-dimensional (3-D) heterometallic framework. Based on the stability and high redox activity of 1, a glassy carbon electrode modified by 1 is used for the construction of an electrochemical biosensor (ECBS). Thus, such 1-based ECBS can sensitively detect the KRAS gene (a key genetic marker for identifying the occurrence of malignant tumors) and displays a low detection limit (0.106 pM), high selectivity, and reproducibility. This work not only provides a feasible approach to prepare novel multicomponent POM-based heterometallic frameworks but also establishes a new platform for biosensing the KRAS gene and extends the application scope of POM-based functional materials.

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.