Dynamic CT-perfusion parameters as indicators of microcirculation: investigation in patients without obstructive coronary artery disease.

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical radiology Pub Date : 2024-12-05 DOI:10.1016/j.crad.2024.106766

M Takafuji, K Kitagawa, M Ishida, M Kubooka, S Nakamura, M Fujita, E Nakamura, S Okabe, K Kawabe, H Sakuma

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引用次数: 0

Abstract

Aim: To investigate the relationship between each CTP parameter and that between CTP parameters and patient characteristics in patients without obstructive coronary artery disease (CAD).

Materials and methods: Seventy-seven (28 female; 65.0±10.3 years) patients with suspected CAD who underwent coronary CT angiography (CCTA) and dynamic CTP with vasodilator stress were included. Patients with obstructive coronary stenosis (≥50%) on CCTA were excluded. Myocardial blood flow (MBF) and myocardial blood volume (MBV) were calculated using the slope and peak of the time-attenuation curves of the myocardium and blood. Perfused capillary blood volume (PCBV), extravascular extracellular volume (EEV), and flow extraction product (FE) were calculated using the extended Tofts model.

Results: MBF, MBV, and PCBV were strongly correlated with each other (all r > 0.80 and all p < 0.001), whereas FE and EEV were strongly correlated with each other (r = 0.88 and p < 0.001). In univariate linear regression analysis, male sex and smoking status were significantly associated with MBF, MBV, and PCBV, while age was significantly associated with FE and EEV (all p < 0.05). In stepwise multivariate analysis, smoking status was independently associated with MBF, MBV. and PCBV, while age was the only factor associated with FE and EEV (all p < 0.05).

Conclusion: FE and EEV may reflect different mechanisms of microvascular dysfunction than MBF, MBV, and PCBV.

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作为微循环指标的动态 CT 灌注参数：对无阻塞性冠状动脉疾病患者的研究。

目的：研究无阻塞性冠状动脉疾病（CAD）患者CTP各参数之间的关系以及CTP参数与患者特征之间的关系：纳入了 77 名（28 名女性；65.0±10.3 岁）疑似 CAD 患者，这些患者均接受了冠状动脉 CT 血管造影术（CCTA）和血管扩张剂应激动态 CTP。CCTA检查发现冠状动脉阻塞性狭窄（≥50%）的患者除外。心肌血流量（MBF）和心肌血容量（MBV）通过心肌和血液的时间-衰减曲线的斜率和峰值计算得出。灌注毛细血管血容量（PCBV）、血管外细胞外容量（EEV）和血流萃取乘积（FE）采用扩展的托夫斯模型计算：结果：MBF、MBV 和 PCBV 之间有很强的相关性（所有 r > 0.80，所有 p < 0.001），而 FE 和 EEV 之间有很强的相关性（r = 0.88，p < 0.001）。在单变量线性回归分析中，男性性别和吸烟状况与 MBF、MBV 和 PCBV 显著相关，而年龄与 FE 和 EEV 显著相关（均 p <0.05）。在逐步多变量分析中，吸烟状况与 MBF、MBV 和 PCBV 独立相关，而年龄是唯一与 FE 和 EEV 相关的因素（所有 p <0.05）：结论：FE和EEV可能反映了与MBF、MBV和PCBV不同的微血管功能障碍机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.