Hailin Xu, Yan Li, Xinying Zhao, Caixia Guo, Yanbo Li
{"title":"Respiratory toxicity of amorphous silica nanoparticles: a review","authors":"Hailin Xu, Yan Li, Xinying Zhao, Caixia Guo, Yanbo Li","doi":"10.1007/s10311-024-01787-3","DOIUrl":null,"url":null,"abstract":"<div><p>Silica nanoparticles exert detrimental effects on the respiratory system, regardless of the exposure route. The adverse outcome pathway framework has been recently developed in toxicological research to characterize the pathways that lead to harmful outcomes. Here, we review the adverse effects of amorphous silica nanoparticles on respiratory health with focus on underlying mechanisms and influencing factors, using the adverse outcome pathway framework for the first time. We found that the increase in reactive oxygen species levels induces oxidative stress and leads to mitochondrial dysfunction. Molecular changes further lead to cellular alterations such as epithelial injury, macrophage, and fibroblast activation. Respiratory cellular damage further induces inflammation and fibrosis in the lungs and airways.</p></div>","PeriodicalId":541,"journal":{"name":"Environmental Chemistry Letters","volume":"23 1","pages":"271 - 319"},"PeriodicalIF":15.0000,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Chemistry Letters","FirstCategoryId":"93","ListUrlMain":"https://link.springer.com/article/10.1007/s10311-024-01787-3","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Silica nanoparticles exert detrimental effects on the respiratory system, regardless of the exposure route. The adverse outcome pathway framework has been recently developed in toxicological research to characterize the pathways that lead to harmful outcomes. Here, we review the adverse effects of amorphous silica nanoparticles on respiratory health with focus on underlying mechanisms and influencing factors, using the adverse outcome pathway framework for the first time. We found that the increase in reactive oxygen species levels induces oxidative stress and leads to mitochondrial dysfunction. Molecular changes further lead to cellular alterations such as epithelial injury, macrophage, and fibroblast activation. Respiratory cellular damage further induces inflammation and fibrosis in the lungs and airways.
期刊介绍：
Environmental Chemistry Letters explores the intersections of geology, chemistry, physics, and biology. Published articles are of paramount importance to the examination of both natural and engineered environments. The journal features original and review articles of exceptional significance, encompassing topics such as the characterization of natural and impacted environments, the behavior, prevention, treatment, and control of mineral, organic, and radioactive pollutants. It also delves into interfacial studies involving diverse media like soil, sediment, water, air, organisms, and food. Additionally, the journal covers green chemistry, environmentally friendly synthetic pathways, alternative fuels, ecotoxicology, risk assessment, environmental processes and modeling, environmental technologies, remediation and control, and environmental analytical chemistry using biomolecular tools and tracers.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
