[History of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Establishment of Disease Concepts, Changes, and the Future of Treatment].

Abstract

The year 2025 marks the 50th anniversary of the publication of the first paper by Dr. P.J. Dyck that uses the disease name "chronic inflammatory polyradiculoneuropathy (CIP)". By combining chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which was previously termed using miscellaneous names, into a single disease concept, a major step forward was made in its diagnosis and treatment. In this paper, we first address the establishment of the disease concept, its acceptance in Japan, and the transition and current status of treatment methods. However, CIDP treatment has not yet been developed to provide satisfactory results for all patients. In the second half of this paper, we discuss therapeutic prospects of the near future based on possible pathological mechanisms.