Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease.

IF 0.8 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Stem cell research Pub Date : 2025-02-01 Epub Date: 2024-12-25 DOI:10.1016/j.scr.2024.103638
Bo Li, Yitong Yang, Yingxin Wang, Didi Shan, Jianing Li, Hongxu Wang, Xiaohan Sun, Yao Tang, Yichang Jiao, Xinbo Ji, Zexin Zhan, Bo Kong, Bo Gao, Yu Wang, Ping Sun, Fuchen Liu
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引用次数: 0

Abstract

Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.

肯尼迪病患者诱导多能干细胞(iPSC)系(inndsu007 - a)的生成
雄激素受体(AR)基因外显子1异常三核苷酸CAG重复扩增已被确定为肯尼迪病(KD)的原因。我们从一名遗传确诊的KD患者的外周血单个核细胞(PBMC)中产生并鉴定了一种人诱导多能干细胞(iPSC)系。通过在RNA和蛋白质水平上表达多个多能性标记物,以及它们向所有三种胚层分化的能力,证实了这些iPSCs的多能性。
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来源期刊
Stem cell research
Stem cell research 生物-生物工程与应用微生物
CiteScore
2.20
自引率
8.30%
发文量
338
审稿时长
55 days
期刊介绍: Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.
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