The relation of anti-phosphatidylserine/prothrombin antibodies and premature rupture of membranes: A retrospective cohort study.

IF 2.9 3区医学 Q3 IMMUNOLOGY

Journal of Reproductive Immunology Pub Date : 2024-12-24 DOI:10.1016/j.jri.2024.104421

Jie Zhang, Ge Zheng, Liqiong Chen, Xueke Guo, Xia Fang, Wenmei Zhang, Yan Tu, Kexin Sun, Zhuhua Cai

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引用次数: 0

Abstract

Background: Existing literature supports the association between atypical phospholipid antibodies - anti-phosphatidylserine/prothrombin antibodies (aPS/PT) and adverse pregnancy outcomes. This study aimed to investigate the relationship between aPS/PT and premature rupture of membranes (PROM).

Methods: A retrospective cohort study analysis was conducted on 408 pregnant women who had experienced at least one unexplained miscarriage. They were tested for aPS/PT IgM and IgG, and clinical data, test results, and follow-up pregnancy outcomes were collected.

Results: A positive correlation was observed between aPS/PT IgM or IgG and PROM in both single-factor and multi-factor regression analysis. After adjusting for potential confounders, the odds ratio (OR) values for aPS/PT IgM and aPS/PT IgG were 1.03 (95 % CI: 1-1.05, P = 0.025) and 1.03 (95 % CI: 1.01-1.06, P = 0.016) respectively. When aPS/PT was divided in three groups, djusted OR values for aPS/PT IgG of the third tertiles compared to the first tertiles (were 2.11(95 % CI: 1.11-4, P = 0.022). Subgroup analysis supported these findings. Curve fitting revealed a linear relationship between aPS/PT IgM and aPS/PT IgG with PROM.

Conclusion: This study suggests that aPS/PT IgG and aPS/PT IgM are independent risk factors for premature rupture of membranes, with aPS/PT IgG showing a higher significance compared to aPS/PT IgM.

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来源期刊

Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.30

自引率

5.90%

发文量

162

审稿时长

10.6 weeks

期刊介绍： Affiliated with the European Society of Reproductive Immunology and with the International Society for Immunology of Reproduction The aim of the Journal of Reproductive Immunology is to provide the critical forum for the dissemination of results from high quality research in all aspects of experimental, animal and clinical reproductive immunobiology. This encompasses normal and pathological processes of: * Male and Female Reproductive Tracts * Gametogenesis and Embryogenesis * Implantation and Placental Development * Gestation and Parturition * Mammary Gland and Lactation.