Diffuse Large B-cell Lymphoma with a Multilobated Nuclear Morphology Harboring t(14;18)(q32;q21) and t(3;22)(q27;q11).

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-26 DOI:10.2169/internalmedicine.4719-24

Masahiro Manabe, Naoyuki Inano, Yuuji Hagiwara, Ki-Ryang Koh

引用次数: 0

Abstract

A 70-year-old woman was admitted to our hospital with dyspnea. Atypical cells with multilobated nuclei were observed in the pleural effusion. Diffuse large B-cell lymphoma (DLBCL) was diagnosed based on a cell block analysis. A chromosomal analysis of lymphoma cells revealed t(14;18)(q32;q21) and t(3;22)(q27;q11). The patient's disease was refractory to chemotherapy, and she died within one year. Although flower-like nuclei are typical of adult T-cell lymphoma/leukemia, similar multilobated nuclei may occur in DLBCL. Although multilobated DCBCL have been reported to have a better prognosis than other forms of DLBCL, the abovementioned translocations may have contributed to the patient's aggressive clinical course.

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弥漫性大b细胞淋巴瘤伴多瓣核形态，包含t (14;18) （q32;q21）和t (3;22) (q27;q11) 1例报告。

一名70岁妇女因呼吸困难入院。胸腔积液中可见核多裂的非典型细胞。弥漫性大b细胞淋巴瘤（DLBCL）的诊断是基于细胞阻滞分析。淋巴瘤细胞的染色体分析显示t (14;18) （q32;q21）和t (3;22) （q27;q11）。病人的病对化疗难以治愈，她在一年内死亡。尽管花状核是成人t细胞淋巴瘤/白血病的典型特征，但在DLBCL中也可能出现类似的多裂核。尽管有报道称，多瓣DCBCL比其他形式的DLBCL预后更好，但上述易位可能导致了患者的侵袭性临床病程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.