Case Reports: Chemokine and Cytokine Profiling in Patients with Herpetic Uveitis.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.2147/IMCRJ.S496941
Nam V Nguyen, Susanne L Linderman, Tolulope Fashina, Max Devine, Christopher D Conrady, Jessica G Shantha, Rafi Ahmed, Steven Yeh
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引用次数: 0

Abstract

Purpose: To report cytokine/chemokine profiles of ocular fluid in two patients with herpetic uveitis.

Methods: Cytokine and chemokine profiling of ocular fluid was performed in two patients with herpetic uveitis. Ocular fluid findings were correlated with disease manifestations and the patients' clinical course.

Observation: Case 1 was a 45-year-old female, who was evaluated for an 11-day history of recurrent redness, and decreased vision in the right eye (OD) and was diagnosed with acute retinal necrosis. Ocular fluid from anterior chamber paracentesis was positive for varicella zoster virus (VZV) via PCR testing. Subsequently, the patient developed proliferative vitreoretinopathy requiring a pars plana vitrectomy. Ocular fluid sample cytokine/chemokine analysis detected IFN-γ, TNF-α, IL-8, IL-18, MIP-1β, IP-10, and MCP-1 with MCP-1 being the most abundant cytokine. Case 2 was a 30-year-old female with a two-month history of progressive pain and decreased vision OD. She was diagnosed with hypertensive anterior uveitis after diagnostic anterior chamber paracentesis. Despite successful therapy for the anterior uveitis, her intraocular pressure remained elevated and required a glaucoma filtration procedure. Ocular fluid sample was collected at the time of surgery for cytokine/chemokine profiles analysis, and levels of 7 cytokines/chemokines were detected including IL-6, IL-8, IL-18, MIP-1β, IP-10, MCP-1, and IL-1RA with IL-1RA being the most abundant cytokine.

Conclusion: Cytokine/chemokine profiles of two patients with herpetic uveitis showed elevated levels of MCP-1, IP-10, IL-8, and IL-18 while IL-1RA was elevated in the chronic phase of hypertensive anterior uveitis. Further studies of cytokines and chemokines will improve our understanding of soluble mediators and potential targets for herpetic uveitis.

病例报告:疱疹性葡萄膜炎患者的趋化因子和细胞因子分析。
目的:报道2例疱疹性葡萄膜炎患者眼液的细胞因子/趋化因子谱。方法:对2例疱疹性葡萄膜炎患者进行眼液细胞因子及趋化因子分析。眼液表现与疾病表现及患者的临床病程相关。观察:病例1是一名45岁的女性,因11天的复发性发红和右眼视力下降(OD)而被评估,诊断为急性视网膜坏死。前房穿刺眼液经PCR检测水痘带状疱疹病毒阳性。随后,患者发展为增生性玻璃体视网膜病变,需要行玻璃体切除手术。眼液样本细胞因子/趋化因子分析检测到IFN-γ、TNF-α、IL-8、IL-18、MIP-1β、IP-10和MCP-1,其中MCP-1是最丰富的细胞因子。病例2为30岁女性,有两个月的进行性疼痛史和视力减退。经前房穿刺诊断为高血压性前葡萄膜炎。尽管前葡萄膜炎治疗成功,但她的眼压仍然升高,需要进行青光眼滤过手术。手术时采集眼液样本进行细胞因子/趋化因子分析,检测7种细胞因子/趋化因子水平,包括IL-6、IL-8、IL-18、MIP-1β、IP-10、MCP-1和IL-1RA,其中IL-1RA是最丰富的细胞因子。结论:2例疱疹性葡萄膜炎患者的细胞因子/趋化因子分析显示,高血压前葡萄膜炎慢性期MCP-1、IP-10、IL-8、IL-18水平升高,IL-1RA水平升高。细胞因子和趋化因子的进一步研究将提高我们对疱疹性葡萄膜炎的可溶性介质和潜在靶点的理解。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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