A Roadmap for Implanting Electrode Arrays to Evoke Tactile Sensations Through Intracortical Stimulation

IF 3.5 2区医学 Q1 NEUROIMAGING

Human Brain Mapping Pub Date : 2024-12-25 DOI:10.1002/hbm.70118

John E. Downey, Hunter R. Schone, Stephen T. Foldes, Charles Greenspon, Fang Liu, Ceci Verbaarschot, Daniel Biro, David Satzer, Chan Hong Moon, Brian A. Coffman, Vahab Youssofzadeh, Daryl Fields, Taylor G. Hobbs, Elizaveta Okorokova, Elizabeth C. Tyler-Kabara, Peter C. Warnke, Jorge Gonzalez-Martinez, Nicholas G. Hatsopoulos, Sliman J. Bensmaia, Michael L. Boninger, Robert A. Gaunt, Jennifer L. Collinger

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引用次数: 0

Abstract

Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain–computer interface (BCI) to restore upper limb function. Evoking tactile sensations of the hand through ICMS requires precise targeting of implanted electrodes. Here we describe the presurgical imaging procedures used to generate functional maps of the hand area of the somatosensory cortex and subsequent planning that guided the implantation of intracortical microelectrode arrays. In five participants with cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand. The imaging and planning procedures developed through this clinical trial provide a roadmap for other BCI studies to ensure the successful placement of stimulation electrodes.

Abstract Image

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植入电极阵列以通过皮质内刺激唤起触觉的路线图。

皮质内微刺激（ICMS）是一种恢复瘫痪患者感觉的方法，是双向脑机接口（BCI）的一部分，用于恢复上肢功能。通过ICMS唤起手的触觉需要植入电极的精确定位。在这里，我们描述了术前成像程序，用于生成手区体感皮层的功能图和随后的规划，指导皮质内微电极阵列的植入。在五个颈椎脊髓损伤的参与者中，在两个研究地点，这个程序成功地使icms诱发的感觉至少定位于手部的前四个手指。通过该临床试验开发的成像和规划程序为其他脑机接口研究提供了路线图，以确保刺激电极的成功放置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Brain Mapping 医学-核医学

CiteScore

8.30

自引率

6.20%

发文量

401

审稿时长

3-6 weeks

期刊介绍： Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.