PTX 3 (pentraxin3) is associated with lung function among people with stable-stage smoking-related chronic obstructive pulmonary disease

IF 2.4 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Xincheng Liu , Rui Li , Maoxu Xia , Yuanyuan Gao , Jiuqi Wang , Li Pan , Zhengjin Xie , Mingming Shen , Guangcui Feng
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引用次数: 0

Abstract

Background

Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory illness. Pentraxin-3 (PTX3) is abnormally elevated in the plasma of patients with acute exacerbation of COPD. However, the role and significance of PTX3 in the clinical diagnosis of COPD remain unclear.

Objectives

This study was to explore the functional role of plasma PTX3 in COPD and its relationship with lung function metrics and influence on the severity of the disease.

Methods

We prospectively recruited 170 patients with stable-stage COPD admitted to our hospital between June 2020 and May 2023 and healthy study participants as study participants. Based on their smoking history, all participants were classified into those with a history of smoking and those without a smoking history.

Results

Stable-stage smoking-related COPD patients exhibited lower values for FEV1(% predicted) and reduced FEV1/FVC ratios, with increased values for smoking index, red cell distribution width, fibrinogen, d-dimer, white blood cell counts, neutrophil to lymphocyte ratio (NLR), Medical Research Council (mMRC) scores, COPD assessment test (CAT) score, and plasma PTX3 level. There was a positive correlation of PTX3 levels with mMRC and CAT scores and a negative correlation with FEV1 % predicted and FEV1/FVC. Increased smoking index and plasma PTX3 and NLR were independent risk factors for exacerbation in stable smoking-related COPD patients. The area under the curve (AUC) for plasma PTX3 in predicting severe COPD was 0.831.

Conclusions

A plasma PTX3 level > 246.2 ng/mL could be a valuable indicator for predicting exacerbations in patients with stable-stage smoking-associated COPD exacerbation.
ptx3(戊曲辛3)与稳定期吸烟相关慢性阻塞性肺疾病患者的肺功能相关
背景:慢性阻塞性肺疾病(COPD)是一种常见的慢性呼吸系统疾病。COPD急性加重患者血浆中penttraxin -3 (PTX3)异常升高。然而,PTX3在COPD临床诊断中的作用和意义尚不清楚。目的:探讨血浆PTX3在COPD中的功能作用及其与肺功能指标的关系及对病情严重程度的影响。方法:前瞻性招募170例2020年6月至2023年5月在我院住院的稳定期COPD患者和健康研究参与者作为研究参与者。根据吸烟史,所有参与者被分为有吸烟史和无吸烟史两组。结果:稳定期吸烟相关COPD患者FEV1值较低(预测值%),FEV1/FVC比值降低,吸烟指数、红细胞分布宽度、纤维蛋白原、d-二聚体、白细胞计数、中性粒细胞与淋巴细胞比值(NLR)、医学研究委员会(mMRC)评分、COPD评估试验(CAT)评分和血浆PTX3水平升高。PTX3水平与mMRC和CAT评分呈正相关,与预测FEV1 %和FEV1/FVC呈负相关。吸烟指数、血浆PTX3和NLR升高是稳定型吸烟相关COPD患者病情加重的独立危险因素。血浆PTX3预测重度COPD的曲线下面积(AUC)为0.831。结论:血浆PTX3水平> 246.2 ng/mL可作为预测稳定期吸烟相关COPD加重的有价值指标。
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来源期刊
Heart & Lung
Heart & Lung 医学-呼吸系统
CiteScore
4.60
自引率
3.60%
发文量
184
审稿时长
35 days
期刊介绍: Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.
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