The intricate "ART" of ICSI.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2024-12-23 DOI:10.1007/s10815-024-03322-3

Olena M Kocur, Philip Xie, Stephanie Cheung, Lily Ng, Angela De Jesus, Zev Rosenwaks, Gianpiero D Palermo

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Abstract

This manuscript explores the intricacies and nuances of the Intracytoplasmic Sperm Injection (ICSI) procedure, drawing on insights from three decades of experience at a specialized center managing numerous cases of male factor infertility. Our center is comprised of an embryology laboratory, an andrology and assisted fertilization laboratory, and a Preimplantation Genetic Testing for Aneuploidy (PGT-A) laboratory, each fostering specialized expertise independently. Collaboration among these laboratories, alongside reproductive physicians and urologists, ensures comprehensive feedback and optimal care for patients undergoing infertility treatment. The manuscript specifically focuses on the andrology laboratory's pivotal role in evaluating and treating infertile patients, highlighting critical preparations for the ICSI procedure, and the key considerations essential to its successful implementation, including the selection of the ideal spermatozoon, oocyte dysmaturity, proper equipment, and most importantly the execution of the procedure itself.

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ICSI复杂的“艺术”。

本文探讨了胞浆内单精子注射（ICSI）程序的复杂性和细微差别，借鉴了三十多年来在一个专门中心管理众多男性因素不育病例的经验。我们的中心由胚胎学实验室、男科和辅助受精实验室、胚胎植入前非整倍体基因检测（PGT-A）实验室组成，每个实验室都独立培养专业知识。这些实验室之间的合作，以及生殖医生和泌尿科医生，确保对接受不孕症治疗的患者进行全面的反馈和最佳的护理。该手稿特别侧重于男科实验室在评估和治疗不孕症患者中的关键作用，强调了ICSI手术的关键准备工作，以及成功实施的关键考虑因素，包括理想精子的选择，卵母细胞不成熟，适当的设备，最重要的是程序本身的执行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.