From food-to-human microplastics and nanoplastics exposure and health effects: A review on food, animal and human monitoring data

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI:10.1016/j.fct.2024.115209

Flavia Ruggieri , Beatrice Battistini , Angela Sorbo , Marta Senofonte , Veruscka Leso , Ivo Iavicoli , Beatrice Bocca

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Abstract

This review figures out the overall status on the presence of microplastics (MPs) and nanoplastics (NPs) in food and their bioaccumulation in animal and human tissues, providing critical insights into possible human health impacts. Data are discussed on both in-vivo and ex-vivo animal and human studies, and the role of physicochemical properties in determining the biological fate and toxicological effects of MPs and NPs. Particular attention is given to dietary exposure assessments, specifically evaluating daily intake through the consumption of contaminated food items. The current limitations in the body of knowledge and some considerations for future assessments are also reported. Overall, there is a pressing need to establish more robust biomarker research and develop standardized methodologies, for a better understanding of MPs and NPs fate and associated effects in more realistic scenarios for their safe consumption. The review underscores the importance of integrating the human biomonitoring into monitoring programs and interdisciplinary research to ultimately inform on MPs and NPs real burden in the human body.

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从食物到人类的微塑料和纳米塑料暴露及其健康影响：对食品、动物和人类监测数据的审查。

本文综述了食品中微塑料（MPs）和纳米塑料（NPs）存在的总体状况及其在动物和人体组织中的生物积累，为可能对人类健康产生的影响提供了重要见解。讨论了体内和离体动物和人体研究的数据，以及物理化学性质在决定MPs和NPs的生物学命运和毒理学效应中的作用。对饮食暴露评估给予了特别关注，特别是评估通过食用受污染食品而获得的每日摄入量。还报告了目前知识体系的局限性和对未来评估的一些考虑。总的来说，迫切需要建立更强大的生物标志物研究和开发标准化的方法，以便更好地了解MPs和NPs的命运和在更现实的情况下安全食用的相关影响。该综述强调了将人体生物监测纳入监测计划和跨学科研究的重要性，以最终了解MPs和NPs在人体中的真正负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.