Catalyst-free coupling of peroxypyrroloindolenines with amines to afford stable peroxyindolenines.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-12-23 DOI:10.1039/d4ob01736f

Xiaoshan Zheng, Menghan Wang, Xianbin Sun, Yu Gao, Haijun Chen

引用次数: 0

Abstract

Here we report a highly efficient method for coupling of peroxypyrroloindolenines with amines under catalyst-free conditions to obtain stable C2-N peroxyindolenines in high yields with remarkable functional group tolerance. Initial studies have shown that compound 13 exhibits potent inhibition of the B16/F10 cell line with an IC₅₀ value of 2.18 μM.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.