Design of an anti-PD-L1-mediated MOF nanodrug delivery system using terpyridine-metal coordination for tumor theranostics.

Abstract

An anti-PD-L1 mediated nanodrug delivery system is developed by modifying the MOF surface and using Tpy-Gd³⁺-Tpy coordination chemistry, enabling the simultaneous delivery of chemotherapy and immunotherapy drugs. The platform enables regulated drug release and integrates multiple imaging modalities, promoting targeted delivery and facilitating tumor diagnosis through FL and MR imaging.