Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-12-19 DOI:10.1016/j.phytochem.2024.114373

Song Wang , De-Zhi Wang , Xia Zhang , Zi-Wei Li , Dong-Hao Lu , Zheng-Jin Jiang , Min Ma , Min Song , Xiao-Qi Zhang

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引用次数: 0

Abstract

Eleven undescribed piperidine alkaloids, arecachines A‒J (1–11), were isolated from the peels of Areca catechu. Compounds 8–11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra. Compounds 1–4, 6, and 8–11 were evaluated for the monoamine oxidases (MAOs) inhibitory activity. Among them, compounds 3, 4, 6, and 10 showed MAOA inhibitory activity with IC₅₀ values of 7.85–55.96 μM, while compounds 1–4, 8, 10, and 11 showed MAOB inhibitory activity with IC₅₀ values of 11.92–77.87 μM.

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槟榔皮中的胡椒碱和双胡椒碱生物碱及其单胺氧化酶抑制活性。

从槟榔果皮中分离得到了11种未描述的胡椒碱生物碱，分别为areachines A-J（1-11）。化合物8-11的特征是双胡椒碱生物碱。通过紫外、红外、hresms、一维和二维核磁共振光谱对其结构进行了表征。对化合物1 ~ 4,6和8 ~ 11的单胺氧化酶抑制活性进行了评价。其中化合物3、4、6、10具有抑制MAOA的活性，IC50值为7.85 ~ 55.96 μM，化合物1 ~ 4、8、10、11具有抑制MAOA的活性，IC50值为11.92 ~ 77.87 μM。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.