Isolated Right Ventricular Metastasis of Hepatocellular Carcinoma: Clinical Findings and Histopathology of an Atypical Presentation

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY
JGH Open Pub Date : 2024-12-20 DOI:10.1002/jgh3.70079
Aaron Yee Shuen See, Pulkit Kasiviswanathan, Masood Pasha Syed, Marta Minervini, Ibrahim Halil Sahin, Michal Krauze
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引用次数: 0

Abstract

Cardiac metastases are a rare site for metastatic hepatocellular carcinoma (HCC). We describe an atypical presentation of an isolated right ventricular metastasis of HCC following successful treatment with no evidence of primary disease recurrence. The case presented as gradually worsening hypertension and erythrocytosis in the setting of normal surveillance scans and alpha-fetoprotein levels. The mass was detected on transthoracic echocardiogram and treated with surgical resection. Histopathological features of the tumor demonstrated features associated with WNT/β-catenin mutated HCC, such as microtrabecular, acinar, and bile staining with positive glutamine synthetase expression.

Abstract Image

肝细胞癌孤立性右心室转移:临床表现和非典型病理表现
心脏转移是转移性肝细胞癌(HCC)的罕见部位。我们描述了一个不典型的表现,孤立的右室转移HCC成功治疗后,没有原发疾病复发的证据。在正常的监视扫描和甲胎蛋白水平下,该病例表现为逐渐恶化的高血压和红细胞增多。经胸超声心动图发现肿块并行手术切除治疗。肿瘤的组织病理学特征显示与WNT/β-catenin突变的HCC相关的特征,如谷氨酰胺合成酶阳性表达的微小梁、腺泡和胆汁染色。
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来源期刊
JGH Open
JGH Open GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
143
审稿时长
7 weeks
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