Emulsion-templated macroporous polycaprolactone: Synthesis, degradation, additive manufacturing, and cell-growth

IF 4.1 2区化学 Q2 POLYMER SCIENCE

Polymer Pub Date : 2024-12-20 DOI:10.1016/j.polymer.2024.127971

Bar Shlomo-Avitan , Majd Machour , Samah Saied Ahmad , Yoav Friedler , Shulamit Levenberg , Michael S. Silverstein

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引用次数: 0

Abstract

PolyHIPEs are macroporous polymers templated within high internal phase emulsions (HIPEs). The ability to tailor the macromolecular and porous structures makes polyHIPEs of interest for three dimensional tissue engineering scaffolds. In this work, polyHIPEs with densities ranging from 0.18 to 0.28 g/cc were synthesized from novel biodegradable poly(ɛ-caprolactone) (PCL) macromers based on methacrylated oligomeric PCL diols of various molecular weights. Different types of internal phases generated porous structures that varied from networks of channels to highly interconnected voids. The crosslinked macromolecular structure limited PCL crystallization, resulting in elastomeric behavior with moduli of around 20 kPa. The HIPEs proved suitable for 3D printing both in air and in an innovative gel-bath. The suitability of the polyHIPEs for tissue engineering applications was indicated by their moduli, by their complete degradation within 4 h in 3 M NaOH, and by mesenchymal stem cells adhering and proliferating. The high level of viability can be attributed to the porosity that enables sufficient nutrient and waste diffusion. These results provide a foundation for designing 3D HIPE inks for printing macroporous tissue engineering scaffolds.

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乳液模板大孔聚己内酯：合成、降解、增材制造和细胞生长

PolyHIPEs是在高内相乳剂（HIPEs）中模板化的大孔聚合物。定制大分子和多孔结构的能力使polyHIPEs成为三维组织工程支架的兴趣。在这项工作中，以不同分子量的甲基丙烯酸化聚己内酯低聚二醇为基础，用新型可生物降解的聚己内酯（PCL）大分子合成了密度为0.18至0.28 g/cc的聚hipes。不同类型的内部相产生的多孔结构从通道网络到高度互连的空隙不等。交联的大分子结构限制了PCL的结晶，导致模量约为20 kPa的弹性体行为。事实证明，HIPEs适用于在空气和创新的凝胶浴中进行3D打印。通过其模量、在3 M NaOH中4小时内完全降解以及间充质干细胞粘附和增殖，表明了多hipes在组织工程应用中的适用性。高水平的生存力可归因于孔隙度，使足够的营养物质和废物扩散。这些结果为大孔组织工程支架3D打印用HIPE油墨的设计提供了基础。

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来源期刊

Polymer 化学-高分子科学

CiteScore

7.90

自引率

8.70%

发文量

959

审稿时长

32 days

期刊介绍： Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.