Correction: Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study

Abstract

Correction : Journal of Hematology & Oncology (2024) 17:47 https://doi.org/10.1186/s13045-024-01565-2

The original article erroneously presents a duplicate of Figure 2A over Figure 2B. The corrected Figure 2 with correct Figure 2B can be viewed ahead in this Correction article.

Fig. 2

A Ct values of plasma methylated OTOP2 for the participants. B Ct values of plasma methylated KCNA3 for the participants. C ROC for OTOP2, KCNA3, or either for all patients with EC versus all controls. D ROC for OTOP2, KCNA3, or either for patients with HGIN versus all controls. E ROC for OTOP2, KCNA3, or either for patients with stage I EC versus all controls. F ROC for OTOP2, KCNA3, or either for patients with stage II EC versus all controls. G ROC for OTOP2, KCNA3, or either for patients with stage III EC versus all controls. H ROC for OTOP2, KCNA3, or either for patients with stage IV EC versus all controls. I The proportion of positive results for OTOP2, KCNA3, or either, in all patients with EC and patients with HGIN, stage I, stage II, stage III, and stage IV EC. J The proportion of positive results for OTOP2, KCNA3, or either, in all controls, HC, and patients with BL, DSM, and non-DSM. Either of KCNA3 and OTOP2 positive was defined as positive, and both negative was defined as negative. K Ct value of plasma methylated OTOP2 in patients with EC before and one day after surgery. L Ct value of plasma methylated KCNA3 in patients with EC before and one day after surgery. M Annular heatmap of the result of combining OTOP2 and KCNA3 in paired plasma samples from before and one day after surgery from the same patients with EC. Black horizontal lines are median and error bars are interquartile range. Ct = cycle threshold. ROC = the receiver operating characteristics curve. EC = esophageal cancer. ESCC = esophageal squamous cell carcinoma. EAC = esophageal adenocarcinoma. HGIN = high-grade intraepithelial neoplasia. HC = healthy control. BL = benign lesion. DSM = digestive system malignancy. P = patient

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Author notes

1. Yan Bian, Ye Gao, Han Lin and Chang Sun contributed equally to this work.

Authors and Affiliations

1. Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China

   Yan Bian, Ye Gao, Han Lin, Chang Sun, Wei Wang, Lei Xin, Zhaoshen Li & Luowei Wang

2. Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, China

   Yan Bian, Ye Gao, Han Lin, Chang Sun, Wei Wang, Lei Xin, Zhaoshen Li & Luowei Wang

3. National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China

   Yan Bian, Ye Gao, Chang Sun, Lei Xin, Zhaoshen Li & Luowei Wang

4. Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

   Siyu Sun

5. Department of Gastroenterology, Henan Provincial People’s Hospital, Zhengzhou, Henan, China

   Xiuling Li

6. Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, Hebei, China

   Zhijie Feng

7. Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China

   Jianlin Ren

8. Department of Thoracic Surgery, Changhai Hospital, Naval Medical University, Shanghai, China

   Hezhong Chen & Chaojing Lu

9. Department of Health Statistics, Naval Medical University, Shanghai, China

   Jinfang Xu

10. Wuhan Ammunition Life-Tech Company, Ltd., Wuhan, Hubei, China

    Jun Zhou & Kangkang Wan

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Correspondence to Lei Xin, Zhaoshen Li or Luowei Wang.

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Bian, Y., Gao, Y., Lin, H. et al. Correction: Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP₂ and KCNA₃: a double-blinded, multicenter, prospective study. J Hematol Oncol 17, 129 (2024). https://doi.org/10.1186/s13045-024-01653-3

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• Published: 21 December 2024

• DOI: https://doi.org/10.1186/s13045-024-01653-3

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