TFA-catalyzed solvent-free dearomative cyanidation of isoquinoline using (Boc)2O as an acylation agent.

IF 2.9 3区 化学 Q1 CHEMISTRY, ORGANIC
Xujin Zhang, Lihua Huang, Ye Zhang, Fanhua Meng, Xiandong Dai, Chunru Cheng, Yongbiao Guo, Zhenhua Gao
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引用次数: 0

Abstract

A TFA-catalyzed dearomative cyanidation of isoquinoline is described, which provides a series of 1-cyanoisoquinolines in high yields under solvent-free conditions. This protocol is operated under mild and environmentally friendly conditions, utilizing readily available and cost-effective starting materials. The reaction features broad functional group compatibility, 100 mmol scale synthesis ability and operational simplicity, making it a significant potential approach for the synthesis of various biologically interesting isoquinolines via α C-cyanation.

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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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