Au nanoparticle-modified hollow carbon spheres as an advanced electrochemical sensing platform for effective detection of homocysteine in human serum.

IF 2.7 3区 化学 Q2 CHEMISTRY, ANALYTICAL
Na Li, Yan Zhang, Dongyu Zhang, Xiaoli Zhang, Ning Wei, Xiuhui Liu
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引用次数: 0

Abstract

It is widely known that homocysteine (Hcy) is associated with the pathogenesis of many clinical diseases, and its quantitative detection can help early treatment of related diseases. The selection of materials with excellent properties is important for the construction of electrochemical sensing platforms and quantitative detection of Hcy. In this study, two nanocomposites, Au nanoparticles/hollow carbon spheres (AuNPs@HCS) and Au nanoparticles/solid carbon spheres (AuNPs@SCS), were prepared first. Then their morphology, structure and electrochemical behavior were investigated. And the comparison found that the HCSs have a large electroactive surface area and outstanding conductivity. Thanks to the catalytic properties of AuNPs and the synergistic effect of HCSs, AuNPs@HCS/GCE showed excellent electrochemical sensing performance for a wide range of Hcy concentrations with a detection limit down to 4.44 nM (S/N = 3). Moreover, the electrochemical mechanism of Hcy on Au@HCS/GCE is discussed in detail. Finally, in the actual serum sample assay, the sensor is used to detect Hcy directly and the recovery rate is satisfactory. This work may provide a valid method for the quantitative determination of Hcy in the future.

众所周知,同型半胱氨酸(Hcy)与许多临床疾病的发病机制有关,对其进行定量检测有助于相关疾病的早期治疗。选择性能优异的材料对于构建电化学传感平台和定量检测 Hcy 具有重要意义。本研究首先制备了金纳米颗粒/空心碳球(AuNPs@HCS)和金纳米颗粒/固体碳球(AuNPs@SCS)两种纳米复合材料。然后研究了它们的形态、结构和电化学行为。比较发现,HCSs 具有较大的电活性表面积和出色的导电性。得益于 AuNPs 的催化特性和 HCSs 的协同作用,AuNPs@HCS/GCE 在较宽的 Hcy 浓度范围内表现出了优异的电化学传感性能,检测限低至 4.44 nM(S/N = 3)。此外,还详细讨论了 Hcy 在 Au@HCS/GCE 上的电化学机理。最后,在实际的血清样品检测中,该传感器直接用于检测 Hcy,回收率令人满意。这项工作为今后定量检测 Hcy 提供了一种有效的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Analytical Methods
Analytical Methods CHEMISTRY, ANALYTICAL-FOOD SCIENCE & TECHNOLOGY
CiteScore
5.10
自引率
3.20%
发文量
569
审稿时长
1.8 months
期刊介绍: Early applied demonstrations of new analytical methods with clear societal impact
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