Pyridoxal 5'-Phosphate (PLP)-Dependent β- and γ-Substitution Reactions Forming Nonproteinogenic Amino Acids in Natural Product Biosynthesis.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-01-24 Epub Date: 2024-12-19 DOI:10.1021/acs.jnatprod.4c01226

Taku Mizutani, Ikuro Abe

引用次数: 0

Abstract

Living organisms synthesize various nonproteinogenic amino acids (NPAAs) as the building blocks of natural products. These NPAAs are often biosynthesized by pyridoxal 5'-phosphate (PLP)-dependent enzymes, which catalyze β- or γ- substitutions. These enzymes contribute to the structural diversification of NPAAs by installing new functional groups to amino acid side chains. Recent developments in genome mining have led to the identification of various PLP-dependent enzymes catalyzing β- or γ- substitutions, which form NPAAs in secondary metabolism. This short review summarizes recently investigated PLP-enzymes catalyzing β- or γ-substitutions in the biosynthesis of NPAAs by covering the literature published from 2015 through 2024.

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吡哆醛5'-磷酸（PLP）依赖性β-和γ-取代反应在天然产物生物合成中形成非蛋白氨基酸。

生物体合成各种非蛋白源氨基酸（NPAAs），作为天然产物的组成成分。这些非蛋白源氨基酸通常由依赖吡哆醛-5'-磷酸（PLP）的酶进行生物合成，这些酶催化β-或γ-取代。这些酶通过在氨基酸侧链上添加新的功能基团，促进了 NPAAs 结构的多样化。基因组挖掘方面的最新进展导致鉴定出了各种依赖 PLP 的酶，这些酶催化 β- 或 γ- 取代，在次级代谢中形成 NPAAs。本短文综述通过对 2015 年至 2024 年发表的文献进行梳理，总结了最近研究的催化 β- 或 γ- 取代的 PLP 酶在 NPAAs 生物合成中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.