Choroid plexus morphology in schizophrenia and early-stage psychosis: A cross-sectional study

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-01-01 DOI:10.1016/j.schres.2024.12.005

Gina Brunner , Ruchika Gajwani , Joachim Gross , Andrew Gumley , Rosanne H. Timmerman , Rebecca Taylor , Rajeev Krishnadas , Stephen M. Lawrie , Matthias Schwannauer , Frauke Schultze-Lutter , Peter J. Uhlhaas , Alessio Fracasso

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引用次数: 0

Abstract

Background

The choroid plexus is an important structure within the ventricular system. Schizophrenia has been associated with morphological changes to the choroid plexus but the presence and extent of alterations at different illness stages is unclear.

Methods

We examined choroid plexus volumes in participants at clinical high-risk for psychosis (N = 110), participants with first-episode psychosis (N = 37), participants with schizophrenia (N = 28), clinical (N = 38) and non-clinical controls (N = 75). Automated segmentation (Gaussian mixture model) was used to estimate choroid plexus volumes from T1 magnetic resonance (MR) images. We then conducted a linear model and Bayes factor analysis to investigate group differences. In addition, the relationship between choroid plexus volumes and clinical characteristics was assessed.

Results

Schizophrenia patients were characterized by increased choroid plexus and ventricular volume while first-episode psychosis and clinical high-risk for psychosis participants showed no differences in choroid plexus volumes. However, choroid plexus volumes in schizophrenia patients did not significantly differ from controls when controlling for ventricular volume. Finally, choroid plexus volumes were not associated with clinical characteristics in the clinical high-risk group.

Conclusion

Our findings suggest that morphological alterations are not specific to the choroid plexus in schizophrenia and early-stage psychosis. Previously reported choroid plexus abnormalities in schizophrenia patients could be explained by changes in ventricular volume.

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精神分裂症和早期精神病的脉络丛形态学：一项横断面研究。

背景：脉络膜丛是脑室系统中的一个重要结构。精神分裂症与脉络膜丛的形态学改变有关，但在不同疾病阶段改变的存在和程度尚不清楚。方法：我们检测了临床精神病高危患者（110例）、首发精神病患者（37例）、精神分裂症患者（28例）、临床对照（38例）和非临床对照（75例）的脉络膜丛容量。采用自动分割（高斯混合模型）从T1磁共振（MR）图像中估计脉络膜丛体积。然后，我们进行了线性模型和贝叶斯因子分析来研究群体差异。此外，我们还评估了脉络膜丛体积与临床特征的关系。结果：精神分裂症患者的特征是脉络膜丛和心室体积增加，而首发精神病患者和临床精神病高危患者的脉络膜丛体积没有差异。然而，当控制心室容积时，精神分裂症患者的脉络膜丛容积与对照组没有显著差异。最后，脉络膜丛体积与临床高危组的临床特征无关。结论：我们的研究结果表明，在精神分裂症和早期精神病患者中，脉络膜丛的形态改变并非特异性的。先前报道的精神分裂症患者脉络膜丛异常可以通过心室容积的改变来解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.