Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.

IF 4.4 1区医学 Q1 ORTHOPEDICS

Journal of Bone and Joint Surgery, American Volume Pub Date : 2025-02-19 Epub Date: 2024-12-18 DOI:10.2106/JBJS.24.00905

Ting Cong, Kyle W Morse, Branden R Sosa, Joseph M Lane, Scott A Rodeo, Matthew B Greenblatt

引用次数: 0

Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

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骨骼干细胞：骨科病理学和组织修复的基础。

骨骼干细胞（ssc）不断补充成熟细胞群，以支持骨骼稳态。ssc通过自我更新重新填充，具有多谱系潜力，并且在体内寿命长。ssc表达反映其谱系身份的细胞表面标记物的特定组合。ssc适应其解剖环境，以支持骨骼行为和病理的区域差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone and Joint Surgery, American Volume 医学-外科

CiteScore

8.90

自引率

7.50%

发文量

660

审稿时长

1 months

期刊介绍： The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, The Journal publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal.