Retinal microvascular changes in systemic lupus erythematosus assessed by optical coherence tomography angiography.

IF 1.9 Q2 OPHTHALMOLOGY

International Journal of Retina and Vitreous Pub Date : 2024-12-18 DOI:10.1186/s40942-024-00617-6

André Ferreira, Luísa Viveiros, Raquel Faria, Francisca Bragança, Ana Carolina Abreu, Daniela Santos, Maria João Furtado, Miguel Lume, Pedro Menéres, José P Andrade

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引用次数: 0

Abstract

Purpose: To assess the retinal microvasculature of Systemic Lupus Erythematosus (SLE) patients using Optical Coherence Tomography Angiography (OCTA).

Methods: Twenty adult SLE patients without disease activity and no ocular manifestations were recruited and cross-sectionally assessed. A demographically similar cohort of healthy subjects was used for comparison. The main outcome is vascular density (VD). As secondary outcomes, foveal avascular zone (FAZ) parameters, total vessel length (TVL), vessel length density (VLD), vessel diameter and tortuosity, branchpoint density (BD) and fractal dimension (FD) were evaluated.

Results: Forty eyes of 40 women (20 SLE patients and 20 healthy subjects) were enrolled with a mean ± SD age of 36.7 ± 9.9 years. In both the superficial and deep capillary plexuses, SLE patients presented significantly lower VD and TVL values, mean vessel diameter and FD (all p < 0.005). No significant differences were found in FAZ values. A negative correlation was found between age and FAZ parameters and between age and TVL, VLD and FD in the superficial capillary plexus (all p < 0.05).

Conclusions: This study supports the evidence of subclinical retinal microvascular changes in adult SLE patients, providing a more comprehensive characterization of vascular changes. We found vessel diameter and length and FD are decreased in SLE.

Trial registration: NCT05863689, 2023-10-19.

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光学相干断层扫描血管造影评估系统性红斑狼疮视网膜微血管改变。

目的：应用光学相干断层扫描血管造影（OCTA）评价系统性红斑狼疮（SLE）患者的视网膜微血管状况。方法：招募20例无疾病活动、无眼部表现的成年SLE患者进行横断面评估。采用人口统计学上相似的健康受试者队列进行比较。主要结果是血管密度（VD）。次要指标为中央凹无血管区（FAZ）参数、血管总长度（TVL）、血管长度密度（VLD）、血管直径和弯曲度、分支点密度（BD）和分形维数（FD）。结果：40例女性（SLE患者20例，健康者20例）40只眼，平均±SD年龄36.7±9.9岁。在浅、深毛细血管丛中，SLE患者的VD、TVL值、平均血管直径和FD均明显降低（均p）。结论：本研究支持成人SLE患者亚临床视网膜微血管改变的证据，为血管改变提供了更全面的表征。我们发现SLE患者血管直径、长度和FD均减少。试验注册：NCT05863689, 2023-10-19。

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来源期刊

International Journal of Retina and Vitreous Medicine-Ophthalmology

CiteScore

3.50

自引率

4.30%

发文量

审稿时长

19 weeks

期刊介绍： International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities