SQUiD: ultra-secure storage and analysis of genetic data for the advancement of precision medicine

IF 10.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genome Biology Pub Date : 2024-12-18 DOI:10.1186/s13059-024-03447-9

Jacob Blindenbach, Jiayi Kang, Seungwan Hong, Caline Karam, Thomas Lehner, Gamze Gürsoy

引用次数: 0

Abstract

Cloud computing allows storing the ever-growing genotype-phenotype datasets crucial for precision medicine. Due to the sensitive nature of this data and varied laws and regulations, additional security measures are needed to ensure data privacy. We develop SQUiD, a secure queryable database for storing and analyzing genotype-phenotype data. SQUiD allows storage and secure querying of data in a low-security, low-cost public cloud using homomorphic encryption in a multi-client setting. We demonstrate SQUiD’s practical usability and scalability using synthetic and UK Biobank data.

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SQUiD：超安全存储和分析基因数据，促进精准医学发展

云计算允许存储对精准医疗至关重要的不断增长的基因型-表型数据集。由于这些数据的敏感性和不同的法律法规，需要额外的安全措施来确保数据隐私。我们开发了SQUiD，一个安全的可查询数据库，用于存储和分析基因型-表型数据。SQUiD允许在低安全性、低成本的公共云中存储和安全查询数据，在多客户端设置中使用同态加密。我们使用合成和UK Biobank数据演示SQUiD的实际可用性和可扩展性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genome Biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

21.00

自引率

3.30%

发文量

241

审稿时长

2 months

期刊介绍： Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.