Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-12-14 DOI:10.1016/j.diagmicrobio.2024.116653

Rania Mhenni , Sarah Dellière , Chiheb Ben Maaouia , Samia Hamane , Benjamin Deniau , Thibault Mahévas , Maité Chaussard , Maxime Coutrot , Lucie Guillemet , Alexandru Cupaciu , Alexandre Pharaboz , Thais Walter , Louis Boutin , Mourad Benyamina , Hélène Corte , Charles Delale , Marc Chaouat , Amélie Guihot , Fanny Lanternier , Alexandre Alanio , Emmanuel Dudoignon

引用次数: 0

Abstract

Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.

查看原文本刊更多论文

抗真菌联合免疫刺激治疗小孢子根霉致难治性皮肤及腹膜毛霉病。

毛霉病是一种真菌感染，通常影响免疫功能低下的患者。在这里，我们报告了一例由小孢子根霉引起的侵袭性皮肤和腹膜毛霉病，成功地用抗真菌治疗、PD-1抑制剂和干扰素- γ联合治疗。我们强调在侵袭性毛霉病难治性病例个体化免疫治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.