{"title":"Modern Methods for the Isolation and Identification of Peptaibols from Filamentos Fungi","authors":"V. V. Sokolov, A. E. Kuvarina, V. S. Sadykova","doi":"10.1134/S0003683824605547","DOIUrl":null,"url":null,"abstract":"<p>Peptaibols are linear or cyclic peptide antibiotics (peptabiotics) characterized by the presence of a non-proteinogenic alpha-aminoisobutyric amino acid produced by filamentous fungi from the Ascomycota phylum. They exhibit a wide range of biological activities against various microbial pathogens, protozoa, viruses, and tumor cells. In this review we described methods for the fungi cultivation, isolation, screening, purification, as well as peptaibol characterization andtheir biological activities. Currently many techniques for each step of their isolation are known, and we will focus on the most commonly used and recently developed chromatographic and spectroscopic methods for their extraction and identification.</p>","PeriodicalId":466,"journal":{"name":"Applied Biochemistry and Microbiology","volume":"60 6","pages":"1074 - 1086"},"PeriodicalIF":1.0000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Biochemistry and Microbiology","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0003683824605547","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Peptaibols are linear or cyclic peptide antibiotics (peptabiotics) characterized by the presence of a non-proteinogenic alpha-aminoisobutyric amino acid produced by filamentous fungi from the Ascomycota phylum. They exhibit a wide range of biological activities against various microbial pathogens, protozoa, viruses, and tumor cells. In this review we described methods for the fungi cultivation, isolation, screening, purification, as well as peptaibol characterization andtheir biological activities. Currently many techniques for each step of their isolation are known, and we will focus on the most commonly used and recently developed chromatographic and spectroscopic methods for their extraction and identification.
期刊介绍：
Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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