Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-12-18 DOI:10.1002/alz.14291

Courtney M. Kloske, Simin Mahinrad, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Brittany Butts, Maria C. Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft, Sandro Da Mesquita, Luke C. Dabin, Davangere Devanand, Violeta Duran-Laforet, Wassim Elyaman, Elizabeth E. Evans, Patricia Fitzgerald-Bocarsly, Kate E. Foley, Ashley S. Harms, Michael T. Heneka, Soyon Hong, Yu-Wen A. Huang, Stephanie Jackvony, Laijun Lai, Yann Le Guen, Cynthia A. Lemere, Shane A. Liddelow, Alfonso Martin-Peña, Anna G. Orr, Francisco J. Quintana, Grace D. Ramey, Jessica E. Rexach, Stacey J. S. Rizzo, Claire Sexton, Alice S. Tang, Jose G. Torrellas, Andy P. Tsai, Lynn van Olst, Keenan A. Walker, Whitney Wharton, Malú Gámez Tansey, Donna M Wilcock

{"title":"Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference","authors":"Courtney M. Kloske, Simin Mahinrad, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Brittany Butts, Maria C. Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft, Sandro Da Mesquita, Luke C. Dabin, Davangere Devanand, Violeta Duran-Laforet, Wassim Elyaman, Elizabeth E. Evans, Patricia Fitzgerald-Bocarsly, Kate E. Foley, Ashley S. Harms, Michael T. Heneka, Soyon Hong, Yu-Wen A. Huang, Stephanie Jackvony, Laijun Lai, Yann Le Guen, Cynthia A. Lemere, Shane A. Liddelow, Alfonso Martin-Peña, Anna G. Orr, Francisco J. Quintana, Grace D. Ramey, Jessica E. Rexach, Stacey J. S. Rizzo, Claire Sexton, Alice S. Tang, Jose G. Torrellas, Andy P. Tsai, Lynn van Olst, Keenan A. Walker, Whitney Wharton, Malú Gámez Tansey, Donna M Wilcock","doi":"10.1002/alz.14291","DOIUrl":null,"url":null,"abstract":"The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"114 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.14291","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.