[Sacituzumab govitecan in the treatment of triple-negative metastatic breast cancer.]

Q3 Medicine
Marta Perachino, Matteo Lambertini
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引用次数: 0

Abstract

The clinical management of triple-negative breast cancer has been very difficult for a long time, being classical chemotherapy the only possible therapeutic approach given the absence of specific targets. However, the therapeutic armamentarium has recently been expanded thanks to the introduction of new molecules, in particular immunotherapy and antibody-drug conjugates (ADCs), which have made it possible to significantly improve the prognosis of this patient population both in the early and advanced settings. Since 2022, the ADC sacituzumab govitecan has been approved by the Italian Medicines Agency (Aifa) for the treatment of advanced/metastatic triple-negative breast cancer pretreated with at least two lines of systemic therapy, of which at least one for metastatic disease. In the collection of case reports, we delved into the available data on the efficacy profile and impact on quality of life of sacituzumab govitecan in several special populations of patients with triple-negative metastatic breast cancer.

长期以来,三阴性乳腺癌的临床治疗一直非常困难,由于缺乏特异性靶点,传统化疗是唯一可能的治疗方法。然而,由于新分子的引入,特别是免疫疗法和抗体药物结合体(ADC)的引入,治疗手段最近得到了扩展,这使得这一患者群体在早期和晚期的预后都得到了显著改善。自 2022 年起,ADCsacituzumab govitecan 已获得意大利药品管理局(Aifa)批准,用于治疗至少接受过两线全身治疗(其中至少一线用于转移性疾病)的晚期/转移性三阴性乳腺癌。在收集的病例报告中,我们深入研究了现有数据,了解了三阴性转移性乳腺癌患者中几个特殊人群使用萨希珠单抗戈维替康的疗效概况及其对生活质量的影响。
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来源期刊
Recenti progressi in medicina
Recenti progressi in medicina Medicine-Medicine (all)
CiteScore
0.90
自引率
0.00%
发文量
143
期刊介绍: Giunta ormai al sessantesimo anno, Recenti Progressi in Medicina continua a costituire un sicuro punto di riferimento ed uno strumento di lavoro fondamentale per l"ampliamento dell"orizzonte culturale del medico italiano. Recenti Progressi in Medicina è una rivista di medicina interna. Ciò significa il recupero di un"ottica globale e integrata, idonea ad evitare sia i particolarismi della informazione specialistica sia la frammentazione di quella generalista.
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