Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review.

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2025-12-01 Epub Date: 2024-12-16 DOI:10.4103/NRR.NRR-D-24-00841
Jie Ji, Chen Gong, Gengxi Lu, Junhang Zhang, Baoqiang Liu, Xunan Liu, Junhao Lin, Patrick Wang, Biju B Thomas, Mark S Humayun, Qifa Zhou
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引用次数: 0

Abstract

Vision restoration presents a considerable challenge in the realm of regenerative medicine, while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach. This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation, emphasizing its potential as a treatment modality for various nerve injuries. By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves, we can delve into their underlying molecular mechanisms. Furthermore, the review underscores the potential of sonogenetics in vision restoration, which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels, thereby modulating the strength of the ultrasound response. We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound, leading to significantly improved therapeutic outcomes.

超声刺激和声遗传学在视力恢复中的潜力:叙述性回顾。
摘要:在再生医学领域,视力恢复是一个相当大的挑战,而超声刺激的最新进展显示出作为一种非侵入性治疗方法的潜力。本文综述了超声刺激神经调节的最新研究,强调了超声刺激神经调节作为一种治疗各种神经损伤的方法的潜力。通过研究不同类型的超声刺激对周围神经和视神经的调节作用,我们可以深入研究其潜在的分子机制。此外,该综述强调了超声遗传学在视力恢复中的潜力,这涉及到利用药理学和遗传学操作来抑制或增强相关机械敏感通道的表达,从而调节超声响应的强度。我们还讨论了如何利用病毒转录等方法使特定神经元或器官对超声波具有高度反应,从而显著改善治疗结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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