{"title":"Four new flavonoids from <i>Sophora flavescens</i> and their antibacterial activities.","authors":"Yun Gao, Xin-Min Li, Fan-Fan Cao, Guo-Qing Long, Jing-Ming Jia, An-Hua Wang","doi":"10.1080/14786419.2024.2440797","DOIUrl":null,"url":null,"abstract":"<p><p>Three new flavanones sophoflavanone C (<b>1</b>), sophoflavanone D (<b>2</b>), sophoflavanone E (<b>3</b>), and one new flavanonol, sophoflavanone F (<b>4</b>), were isolated from the ethanol extract of the root bark of <i>Sophora flavescens</i>. The structures of these compounds were identified by UV spectroscopy, high-resolution electrospray ionisation mass spectrometry (HRESIMS), nuclear magnetic resonance spectroscopy (NMR), and comparison with previous reports. Additionally, the antibacterial activity of compounds <b>1</b>-<b>4</b> against eight bacterial strains, including four Gram-positive bacterial strains and four Gram-negative bacterial strains, was determined using the micro broth dilution method. Both isopentenyl flavones, sophoflavanone C (<b>1</b>) and sophoflavanone F (<b>4</b>) exhibited significant antibacterial activity against the Gram-positive bacterial strains.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2440797","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Three new flavanones sophoflavanone C (1), sophoflavanone D (2), sophoflavanone E (3), and one new flavanonol, sophoflavanone F (4), were isolated from the ethanol extract of the root bark of Sophora flavescens. The structures of these compounds were identified by UV spectroscopy, high-resolution electrospray ionisation mass spectrometry (HRESIMS), nuclear magnetic resonance spectroscopy (NMR), and comparison with previous reports. Additionally, the antibacterial activity of compounds 1-4 against eight bacterial strains, including four Gram-positive bacterial strains and four Gram-negative bacterial strains, was determined using the micro broth dilution method. Both isopentenyl flavones, sophoflavanone C (1) and sophoflavanone F (4) exhibited significant antibacterial activity against the Gram-positive bacterial strains.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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