Refractory Vulvovaginal Lichen Planus Responding to Oral Tofacitinib

IF 2.2 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2024-12-16 DOI:10.1111/ajd.14403

Benetta Benny, Anupama Bains, Aasma Nalwa

引用次数: 0

Abstract

Erosive vulvovaginal lichen planus is a severe form of Lichen planus (LP) that can result in chronic scarring if not treated. It can cause narrowing of the introitus, resulting in pain, itch, dyspareunia, dysuria, and recurrent urinary tract infections caused by retention of urine. Therefore, an effective and safer therapeutic approach is required. Here, we present a case of refractory erosive vulvovaginal LP, which showed remarkable response to oral tofacitinib, a Janus kinase 1 and 3 (JAK1/3) inhibitor, which was well tolerated.

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口服托法替尼治疗难治性外阴阴道扁平苔藓。

糜烂外阴阴道扁平苔藓是一种严重形式的扁平苔藓（LP），可导致慢性疤痕，如果不治疗。它会引起尿道狭窄，导致疼痛、瘙痒、性交困难、排尿困难和尿潴留引起的反复尿路感染。因此，需要一种有效和安全的治疗方法。在这里，我们报告了一例难治性糜烂性外阴阴道LP，该病例对口服托法替尼（一种Janus激酶1和3 （JAK1/3）抑制剂）有显著的反应，耐受性良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.