SNAr Reactions Using Continuous Plug Flow...in Aqueous Biphasic Media

IF 7.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ACS Sustainable Chemistry & Engineering Pub Date : 2024-12-17 DOI:10.1021/acssuschemeng.4c08612

Madison J. Wong, Kaitlyn M. Freiberg, Trevor Reynafarje Jones, Kylee B. Dismuke Rodriguez, Alex B. Wood, Bruce H. Lipshutz

引用次数: 0

Abstract

New plug-flow opportunities for carrying out S_NAr reactions are disclosed using water mixed with the green and separable/recyclable cosolvent 2-MeTHF. This approach enables C–O, C–N, and C–S bond formations. Several features characteristic of this sustainable technology are highlighted, such as recycling of the aqueous reaction medium, applications to several intermediates en route to numerous active pharmaceutical ingredients, and a new “flow-to-batch-to-flow” sequence of reactions demonstrating the possibilities for both time and pot economies to be realized.

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利用水与可分离/可回收的绿色助溶剂 2-MeTHF 混合，为进行 SNAr 反应提供了新的塞流式机会。这种方法可以形成 C-O、C-N 和 C-S 键。重点介绍了这种可持续技术的几个特点，如水性反应介质的循环利用、应用于多种活性药物成分生产过程中的多种中间体，以及新的 "流程-批次-流程 "反应序列，展示了实现时间经济和釜经济的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Sustainable Chemistry & Engineering CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

13.80

自引率

4.80%

发文量

1470

审稿时长

1.7 months

期刊介绍： ACS Sustainable Chemistry & Engineering is a prestigious weekly peer-reviewed scientific journal published by the American Chemical Society. Dedicated to advancing the principles of green chemistry and green engineering, it covers a wide array of research topics including green chemistry, green engineering, biomass, alternative energy, and life cycle assessment. The journal welcomes submissions in various formats, including Letters, Articles, Features, and Perspectives (Reviews), that address the challenges of sustainability in the chemical enterprise and contribute to the advancement of sustainable practices. Join us in shaping the future of sustainable chemistry and engineering.