Recent Advances in Poly(amino acids), Polypeptides, and Their Derivatives in Drug Delivery

IF 5.8 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2024-12-17 DOI:10.1039/d4nr04481a

Huilin Yuan, Mingxia Jiang, Huapan Fang, Huayu Tian

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引用次数: 0

Abstract

Poly(amino acids), polypeptides, and their derivatives have demonstrated significant potential as biodegradable biomaterials in the field of drug delivery. As degradable drug carriers, they can effectively load or conjugate drug molecules including small molecule drugs, nucleic acids, peptides, and protein-based drugs, enhancing the stability and targeting of the drugs in vivo. This strategy ultimately facilitates precise drug delivery and controlled release, thereby improving therapeutic efficacy and reducing side effects within the body. This review systematically describes the structural characteristics and preparation methods of poly(amino acids) and polypeptides, summarizes the advantages of poly(amino acids), polypeptides, and their derivatives in drug delivery, and detailedly introduces the latest advancements in this area. The review also discusses current challenges and opportunities associated with poly(amino acids), peptides, and their derivatives, and offers insights into the future directions for these biodegradable materials. This review aims to provide valuable references for scientific research and clinical translation of biodegradable biomaterials based on poly(amino acids) and peptides.

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聚氨基酸、多肽及其衍生物在给药领域的最新进展

聚（氨基酸）、多肽及其衍生物作为生物可降解生物材料在药物输送领域已显示出巨大的潜力。作为可降解药物载体，它们可以有效地负载或共轭药物分子，包括小分子药物、核酸、肽和蛋白质类药物，增强药物在体内的稳定性和靶向性。这种策略最终有助于精确给药和控制释放，从而提高疗效并减少体内副作用。这篇综述系统地介绍了聚（氨基酸）和多肽的结构特点和制备方法，总结了聚（氨基酸）、多肽及其衍生物在给药方面的优势，并详细介绍了这一领域的最新进展。综述还讨论了当前与聚（氨基酸）、多肽及其衍生物相关的挑战和机遇，并对这些生物可降解材料的未来发展方向提出了见解。本综述旨在为基于聚（氨基酸）和肽的可生物降解生物材料的科学研究和临床转化提供有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.