Monoclonal Gammopathy-Associated Neuropathy.

IF 2.7 3区 医学 Q2 HEMATOLOGY
Shayna Sarosiek, Christopher T Doughty, Jorge J Castillo
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引用次数: 0

Abstract

Purpose of review: Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with an IgM monoclonal gammopathy or Waldenström macroglobulinemia.

Recent findings: There are multiple potential ways that the paraprotein may result in peripheral neuropathy. The diagnosis and management of monoclonal gammopathy-associated PN are challenging and necessitate a concerted effort between the hematologist/oncologist and the neurologist. This review describes the most common PN syndromes associated with monoclonal gammopathy, such as anti-myelin-associated glycoprotein neuropathy, light chain amyloidosis, cryoglobulinemia, POEMS, CANOMAD, and others. We also review the therapies used to treat these conditions.

综述目的:周围神经病变(PN)更常见于单克隆丙种球蛋白病患者,尤其是 IgM 单克隆丙种球蛋白病或瓦尔登斯特伦巨球蛋白血症患者:副蛋白可能通过多种途径导致周围神经病变。单克隆丙种球蛋白病相关 PN 的诊断和治疗具有挑战性,需要血液/肿瘤科医生和神经科医生共同努力。本综述介绍了最常见的与单克隆丙种球蛋白病相关的 PN 综合征,如抗髓鞘相关糖蛋白神经病、轻链淀粉样变性、冷球蛋白血症、POEMS、CANOMAD 等。我们还回顾了用于治疗这些疾病的疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: his journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hematologic malignancy. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as leukemia, lymphoma, myeloma, and T-cell and other lymphoproliferative malignancies. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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