Formation of Poly-L-Lysine-Porphyrin Derivative Complex Exhibiting Diminished Dark Toxicity in Aqueous Solutions and High Photodynamic Activity.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2024-12-15 DOI:10.1002/cbic.202400926

Yusuke Egashira, Nanami Kono, Naoki Tarutani, Kiyofumi Katagiri, Shodai Hino, Keita Yamana, Riku Kawasaki, Atsushi Ikeda

引用次数: 0

Abstract

Poly-L-lysine (PLL) displays a high solubilizing ability for hydrophobic guest molecules, and when in complexes with guest molecules, it exhibits a high intracellular uptake. However, its high cytotoxicity, originating from its cationic character, significantly limits its applications in biological and medicinal chemistry. In this study, the amount of free PLL in an aqueous solution of a PLL-porphyrin complex was immensely reduced, resulting in considerably lower dark toxicity than that of the free PLL. Furthermore, the PLL-porphyrin complex exhibited high photodynamic activity under photoirradiation at 610-740 nm.

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形成聚-L-赖氨酸-卟啉衍生物复合物，在水溶液中的暗毒性减弱，光动力活性高。

聚 L-赖氨酸（PLL）对疏水性客体分子具有很强的增溶能力，当与客体分子复合时，它在细胞内的吸收率很高。然而，由于其阳离子特性，它具有较高的细胞毒性，这大大限制了它在生物和药物化学中的应用。在这项研究中，PLL-卟啉复合物水溶液中的游离 PLL 量大大减少，因此其暗色毒性大大低于游离 PLL。此外，在 610-740 纳米波长的光照射下，PLL-卟啉复合物表现出很高的光动力活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).