Isolation of 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from a new source, Haplanthodes tentaculatus: characterization and anticancer activity.
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Abstract
This study explores the anticancer properties of Haplanthodes tentaculatus, a plant indigenous to the Western Ghats of India. We isolated and characterised 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from H. tentaculatus, previously unreported in this plant, using preparative HPLC, NMR, and HRMS techniques. The compound's molecular structure and purity were confirmed, and its biological activity was evaluated on the MDA-MB-231 breast cancer cell line using the MTT assay. The compound exhibited notable cytotoxic effects with an IC50 value of 155.21 ± 1.59 sM. This work validates the therapeutic capabilities of H. tentaculatus and contributes to ongoing research on natural substances for anticancer drug development. The results suggest that H. tentaculatus could be a promising source of bioactive compounds, opening new possibilities for cancer therapy approaches.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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