Screening of novel lactic acid bacteria with high induction of IgA production, dendritic cell activation, and IL-12 production.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-12-13 DOI:10.1093/bbb/zbae196

Keigo Tsuruno, Takashi Mawatari, Yukimasa Tanaka-Azuma, Atsushi Yamatsu, Soichi Tanabe

引用次数: 0

Abstract

In this study, we screened 308 lactic acid bacteria strains for high immunoglobulin A (IgA) production, dendritic cell activation, and IL-12 production using human derived cells. Among them, Lactobacillus helveticus GCL1815 demonstrated superior performance in all aspects, indicating its remarkable potential for immunomodulatory functions in both innate and adaptive immunity.

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具有高诱导IgA生成、树突状细胞激活和IL-12生成的新型乳酸菌的筛选。

在这项研究中，我们利用人体衍生细胞对 308 株乳酸菌进行了筛选，以检测它们是否能产生大量免疫球蛋白 A（IgA）、树突状细胞活化和 IL-12 生成。其中，螺旋乳杆菌 GCL1815 在所有方面都表现优异，表明其在先天性免疫和适应性免疫方面都具有显著的免疫调节功能潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).