Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2025-02-01 DOI:10.1016/j.critrevonc.2024.104588

Chou-Yi Hsu , Harikumar Pallathadka , Saade Abdalkareem Jasim , Jasur Rizaev , Dmitry Olegovich Bokov , Ahmed Hjazi , Shriya Mahajan , Yasser Fakri Mustafa , Beneen Husseen , Mohammed Abed Jawad

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Abstract

A major advance in cancer treatment has been the development and refinement of cancer immunotherapy. The discovery of immunotherapies for a wide range of cancers has revolutionized cancer treatment paradigms. Despite relapse or refractory disease, immunotherapy approaches can prolong the life expectancy of metastatic cancer patients. Multiple therapeutic approaches and agents are currently being developed to manipulate various aspects of the immune system. Oncolytic viruses, cancer vaccines, adoptive cell therapies, monoclonal antibodies, cytokine therapies, and inhibitors of immune checkpoints have all proven successful in clinical trials. There are several types of immunotherapeutic approaches available for treating cancer, and others are being tested in preclinical and clinical settings. Immunotherapy has proven successful, and many agents and strategies have been developed to improve its effectiveness. The purpose of this article is to present a comprehensive overview of current immunotherapy approaches used to treat cancer. Cancer immunotherapy advancements, emerging patterns, constraints, and potential future breakthroughs are also discussed.

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癌症免疫治疗的创新：近期突破和未来方向的综合概述。

癌症治疗的一个重大进展是癌症免疫疗法的发展和完善。多种癌症的免疫疗法的发现已经彻底改变了癌症治疗模式。尽管复发或难治性疾病，免疫治疗方法可以延长转移性癌症患者的预期寿命。目前正在开发多种治疗方法和药物来控制免疫系统的各个方面。溶瘤病毒、癌症疫苗、过继细胞疗法、单克隆抗体、细胞因子疗法和免疫检查点抑制剂在临床试验中都被证明是成功的。有几种类型的免疫治疗方法可用于治疗癌症，其他方法正在临床前和临床环境中进行测试。免疫疗法已被证明是成功的，许多药物和策略已被开发出来以提高其有效性。本文的目的是全面概述目前用于治疗癌症的免疫治疗方法。癌症免疫治疗的进展，新模式，限制和潜在的未来突破也进行了讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.