A US-Based Multi-Site Pilot to Screen Hepatitis B Surface Antigen-Positive Patients for Hepatitis D

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Maggie Li, Bijou Hunt, Bindu Balani, Chinwe Ogedegbe, Peter Gordon, Joshua Hayden, Nancy Glick, Anita Chang, Su Wang, Mitchell Caponi, Lisa Yarber-Cambron, Sandeep Bhat, Tyshea Ward, Madhu Suryadevara
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Abstract

Hepatitis D (HDV) is a severe infection with well-recognised clinical ramifications that remains relatively neglected and underdiagnosed; consequently, the epidemiology of HDV is poorly characterised, both in the United States and globally. In 2022, a pilot project involving eight healthcare institutions was undertaken to ascertain the prevalence of HDV in healthcare institutions with an HBV seropositivity of at least 1%, describe the characteristics of patients testing positive for HDV, and evaluate diagnostic and laboratory processes of HDV screening. From August 2022 to April 2024, a total of 106,693 patients were tested for HBsAg, of whom 65,341 (61.2%) were female and 40,863 (38.3%) were male, with a mean age of 47 years. The overall HBsAg positivity rate was 1.04% (n = 1112). Among the HBsAg+ samples, 645 (58.0%) underwent HDV Ab testing. The HDV Ab positivity rate was 0.81% (n = 9), with 2 cases of HDV RNA positivity (0.18%). The incomplete testing reflects several challenges associated with screening for both HBV and HDV. Further research is necessary to better understand the epidemiology and burden of HDV in the United States and considerations for implementation.

Abstract Image

丁型肝炎(HDV)是一种严重感染,具有公认的临床后果,但仍相对被忽视和诊断不足;因此,无论是在美国还是在全球,HDV 的流行病学特征都不甚明了。2022 年,八家医疗机构参与了一个试点项目,以确定 HDV 在 HBV 血清阳性率至少为 1%的医疗机构中的流行率,描述 HDV 检测呈阳性的患者的特征,并评估 HDV 筛查的诊断和实验室流程。从 2022 年 8 月到 2024 年 4 月,共有 106,693 名患者接受了 HBsAg 检测,其中 65,341 人(61.2%)为女性,40,863 人(38.3%)为男性,平均年龄为 47 岁。总体 HBsAg 阳性率为 1.04%(n = 1112)。在 HBsAg+ 样本中,有 645 份(58.0%)接受了 HDV Ab 检测。HDV Ab 阳性率为 0.81%(n = 9),HDV RNA 阳性 2 例(0.18%)。检测不完全反映了与同时筛查 HBV 和 HDV 相关的一些挑战。为了更好地了解 HDV 在美国的流行病学和负担以及实施时的注意事项,有必要开展进一步的研究。
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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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