The Effect of Using Perioperative Platelet-Rich Plasma on Wound Healing Rate and Prevention of Salivary Fistula Formation in Patients Undergoing Partial Parotidectomy.

IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY
Selim Kul, Sema Zer Toros, Çağrı Becerik, Lütfü Şeneldir, Sebahat Aksaray
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引用次数: 0

Abstract

Objectives: This study aims to examine the effects of autologous platelet-rich plasma (PRP), which increases new connective tissue synthesis and revascularisation, on healing in parotid surgery wounds, prevention of salivary fistula formation, drain removal time and hospitalisation in the postoperative period.

Materials and methods: Fifty-four patients who had an operation on partial parotidectomy were randomised, and then two groups were created. PRP was obtained by centrifuging the blood taken from the patients in the study group at the end of the surgery. This obtained PRP was injected into the surgical site, and then the wound flap was closed by suturing. Patients were evaluated for parameters such as the development of salivary fistula, duration of drain removal, discharge time and all other complications during the postoperative 4 weeks.

Results: Drain removal and discharge times of the PRP group cases were statistically shorter than those in the control group. The rate of development of a salivary fistula was remarkably high in the control group, but it was not statistically significant. A statistically significant correlation was found between the location of the compared tumour, the volume of material removed and the incidence of all complications.

Conclusions: PRP reduced the duration of drain removal and discharge times for those who had an operation on partial parotidectomy. Thus, the decreased discharge time provides both reduced health costs and reduced risk of developing nosocomial infections. Although it was not statistically significant, a significant difference was observed in the rates of salivary fistula development.

研究目的自体血小板丰富血浆(PRP)可增加新结缔组织的合成和血管再造,本研究旨在探讨自体血小板丰富血浆对腮腺手术伤口愈合、预防涎瘘形成、术后引流管拔除时间和住院时间的影响:54名接受腮腺部分切除手术的患者被随机分为两组。研究组患者在手术结束后离心取血,获得 PRP。将获得的 PRP 注入手术部位,然后缝合伤口皮瓣。在术后四周内,对患者进行参数评估,如唾液瘘的发生、引流管拔除时间、出院时间和所有其他并发症:结果:据统计,PRP 组病例的引流管拔除时间和出院时间均短于对照组。对照组的涎瘘发生率明显较高,但无统计学意义。比较肿瘤的位置、移除的材料量和所有并发症的发生率之间存在统计学意义上的明显相关性:PRP缩短了腮腺部分切除手术患者移除引流管的时间和出院时间。因此,出院时间的缩短既降低了医疗成本,又降低了发生院内感染的风险。虽然没有统计学意义,但在涎瘘发生率方面观察到了显著差异。
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来源期刊
Clinical Otolaryngology
Clinical Otolaryngology 医学-耳鼻喉科学
CiteScore
4.00
自引率
4.80%
发文量
106
审稿时长
>12 weeks
期刊介绍: Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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