Exploring the Function of OPTN From Multiple Dimensions

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2024-12-13 DOI:10.1002/cbf.70029

Yanan Guo, Yixiao Tian, Peng Xia, Xinyue Zhou, Xiaohui Hu, Zhao Guo, Pengfei Ji, Xinyi Yuan, Daosen Fu, Keyu Yin, Rong Shen, Degui Wang

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引用次数: 0

Abstract

Autophagy is an essential intracellular degradation system responsible for delivering cytoplasmic components to lysosomes. Within this intricate process, optineurin (OPTN), an autophagy receptor, has attracted extensive attention due to its multifaceted roles in the autophagy process. OPTN is regulated by various posttranslational modifications and actively participates in numerous signaling pathways and cellular processes. By exploring the regulatory mechanism of OPTN posttranslational modification, we can further understand the critical role of protein posttranslational modification in biological progress, such as autophagy. Additionally, OPTN is implicated in many human diseases, including rheumatoid arthritis, osteoporosis, and infectious diseases. And we delve into the inflammatory pathways regulated by OPTN and clarify how it regulates inflammatory diseases and cancer. We aim to enhance the understanding of OPTN's multifaceted functions in cellular processes and its implications in the pathogenesis of inflammatory diseases and cancer.

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从多维度探索OPTN的功能。

自噬是一种重要的细胞内降解系统，负责将细胞质成分传递给溶酶体。在这一复杂的过程中，自噬受体OPTN因其在自噬过程中的多方面作用而引起了广泛的关注。OPTN受多种翻译后修饰的调控，积极参与多种信号通路和细胞过程。通过探索OPTN翻译后修饰的调控机制，我们可以进一步了解蛋白质翻译后修饰在自噬等生物过程中的关键作用。此外，OPTN与许多人类疾病有关，包括类风湿关节炎、骨质疏松症和传染病。我们深入研究了由OPTN调控的炎症途径，阐明了它是如何调控炎症性疾病和癌症的。我们的目标是加强对OPTN在细胞过程中的多方面功能及其在炎症性疾病和癌症发病机制中的意义的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.